Conformational Studies of 1,2-Disubstituted Indan Derivatives by Nuclear Magnetic Resonance Spectroscopy

John D Roberts Studies of Conformational Equilibria and Equilibration by Nuclear Magnetic Resonance Spectroscopy

The study of conformational equilibria and equilibration by nuclear 111agnet£c resonance in cyclic co111pou11ds has been found lo be considerably facilitated by use of 19 F spectra of gemfluoro derivatives. R esults obtained zcith cyclohexane, cis-decali11, and cyclohepta11e ring systems were re·vieu·ed zcith particular emphasis on the degree with which conclusions drawn might also be applicabl...

Conformational studies on tocinamide and deaminotocinamide by 220 MHz nuclear magnetic resonance spectroscopy.

The 220 MHz spectra of tocinamide and deaminotocinamide, the ring moieties of oxytocin and of deamino-oxytocin, respectively, were investigated in [U-(2)H]dimethylsulfoxide solution. Extensive decoupling and exchange experiments allow complete spectral assignment and determination of many coupling constants. Circular dichroism spectra assigned a right-hand screw sense to the C-S-S-C group. The ...

Detection of new temperature-dependent conformational transition in lysozyme by carbon-13 nuclear magnetic resonance spectroscopy.

A specific temperature-dependent conformational transition of hen egg-white lysozyme, occurring between 20 degree C and 30 degree C in solution, has been detected by 13-C-nuclear magnetic resonance spectroscopy. Selective changes in the chemical shifts of aromatic residues, together with differences in the chemical shifts, and nuclear Overhauser enhancement in the carbonyl, carboxyl, and alpha-...

Proton Nuclear Magnetic Resonance Spectroscopy

18. Nuclear Magnetic Resonance Spectroscopy

Nuclear Magnetic Resonance (NMR) is a spectroscopic technique widely used by organic chemists. NMR provides details about the location, number and environment of specific types of atoms within a sample. The proper interpretation of this information allows detailed chemical structures to be discerned. The same basic instrumentation used in this week’s experiment is used in physician offices when...